Article

Prostaglandin E <sub>2</sub> controls the metabolic adaptation of T cells to the intestinal microenvironment

2023-03-15

Abstract excerpt

Immune cells must adapt to different environments during the course of an immune response. We studied the adaptation of CD8 + T cells to the intestinal microenvironment and how this process shapes their residency in the gut. CD8 + T cells progressively remodel their transcriptome and surface phenotype as they acquire gut residency, and downregulate expression of mitochondrial genes. Human and mouse gut-resident...

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Identifiers and source

Literature Corpus work: 10098957-bbc7-5137-8b85-673cb86b30ab
DOI: 10.1101/2023.03.13.532431

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