Article
TREM2 in CNS homeostasis and neurodegenerative disease.
Molecular neurodegeneration - 4 Sept 2015
Painter Meghan M, Atagi Yuka, Liu Chia-Chen, Rademakers Rosa, Xu Huaxi, Fryer John D, Bu Guojun
Abstract excerpt
Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and regeneration. The innate immune receptor and its adaptor protein—triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12)—possess the ability to modulate critical cellular functions via...
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