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Article

Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders.

Cell reports - 27 Jun 2023

Gao Han, Di Jiawei, Clausen Bettina Hjelm, Wang Nanxiang, Zhu Xizhong, Zhao Tianlun, Chang Yanyu, Pang Mao, Yang Yang, He Ronghan, Wang Yuge, Zhang Liangming, Liu Bin, Qiu Wei, Lambertsen Kate Lykke, Brambilla Roberta, Rong Limin

Abstract excerpt

Triggering receptor expressed on myeloid cell 2 (TREM2) signaling often drives opposing effects in traumatic versus demyelinating CNS disorders. Here, we identify two distinct phenotypes of microglia and infiltrating myeloid populations dependent on TREM2 expression levels at the acute stage and elucidate how they mediate the opposing effects of TREM2 in spinal cord injury (SCI) versus multiple sclerosis animal...

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Identifiers

PMID: 37289590
DOI: 10.1016/j.celrep.2023.112629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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