Article

Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication

2021-02-15

Abstract excerpt

Therapeutics that promote oligodendrocyte survival and remyelination are needed to restore neurological function in demyelinating diseases. Sphingosine 1-phosphate (S1P) is an essential lipid metabolite that signals through five G-protein coupled receptors. S1P receptor agonists such as Fingolimod are valuable immunosuppressants used to treat multiple sclerosis, and promote oligodendrocyte survival. However, the r...

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Literature Corpus work: f03ad9e2-ad01-5644-aa79-7b184958b7f8
DOI: 10.1101/2021.02.14.431183

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