Article

Microglial CX3CR1 <sup>I249/M280</sup> variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model

2021-06-07

Abstract excerpt

Microglia have been implicated in multiple sclerosis (MS) pathogenesis. The fractalkine receptor CX3CR1 regulates the activation of pathogenic microglia in models of MS and the human polymorphic CX3CR1 I249/M280 (h CX3CR1 I249/M280 ) variant increases MS disease progression. However, the role of h CX3CR1 I249/M280 on microglial activation and central nervous system repair and regenerative mechanisms remain unkn...

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Literature Corpus work: 4cca7279-92ca-513e-ac86-87affc0b8e04
DOI: 10.1101/2021.06.06.447262

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