Article

Trem2 deficiency impairs recovery and phagocytosis by dysregulating myeloid gene expression during virus induced demyelination

2022-06-29

Abstract excerpt

<h4>Background: </h4> Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contrast, Trem2 functions can exacerbate tissue damage during respiratory viral or liver infections. We therefore investigated the role of Trem2 in a viral encephalomyelitis model associated with prominent Th1 mediated antiviral immunity leading to demyelination. Method Wild typ...

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Literature Corpus work: 7129606d-5b1c-5a7a-94fe-f374203103c4
DOI: 10.21203/rs.3.rs-1769173/v1

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