Article

AD-linked R47H- <i>TREM2</i> mutation induces disease-enhancing proinflammatory microglial states in mice and humans

2020-07-25

Abstract excerpt

<h4>ABSTRACT</h4> The hemizygous R47H variant of TREM2 , a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD). In this study, we identified a subpopulation of microglia with disease-enhancing proinflammatory signatures associated with the R47H mutation in human AD brains and tauopathy mouse brains. Using transcriptomic analysis at the single-nuclei level from AD patients...

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Literature Corpus work: 02c103bd-a6a9-5690-98c6-4085c1a18f2f
DOI: 10.1101/2020.07.24.218719

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