Article

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

2022-06-01

Abstract excerpt

<title>Abstract</title> <p>Background Amongst risk alleles associated with late-onset Alzheimer’s disease (AD), those that converged on the regulation of microglia activity have emerged as central to disease progression. Yet, how canonical amyloid-β (Aβ) and tau pathologies regulate microglia subtypes during the progression of AD remains poorly understood. Methods We use single-cell RNA-sequencing to profile mi...

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Literature Corpus work: 924f908e-7dcc-5698-98e0-641e662a735f
DOI: 10.21203/rs.3.rs-1598611/v1

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