Article

Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia

2025-12-01

Abstract excerpt

Aging is the primary risk factor for clonal hematopoiesis and the development of hematologic malignancies ( 1–5 ), yet the selective pressures that shape stem cell behavior and clonal expansion during aging remain poorly defined. Here, we identify proteostasis stress as a central driver of hematopoietic stem cell (HSC) aging and clonal evolution. We show that Heat shock factor 1 (Hsf1) is activated in aging HSCs...

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Literature Corpus work: e5891e66-e1eb-5056-97fc-a48b43b2949f
DOI: 10.1101/2025.11.27.690982

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