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Deciphering the evolving niche interactome of human hematopoietic stem cells from ontogeny to aging

4 Dec 2024

Abstract excerpt

Hematopoietic stem cells (HSC) reside within specialized microenvironments that undergo dynamic changes throughout development and aging to support HSC function. However, the evolving cell-cell communication networks within these niches remain largely unexplored. This study integrates single-cell RNA sequencing datasets to systematically characterize the HSC niche interactome from ontogeny to aging. We...

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PMID: 39698109
DOI: 10.3389/fmolb.2024.1479605

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