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An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans

2025-09-04

Abstract excerpt

Aging of the blood system impacts systemic health and can be traced to hematopoietic stem cells (HSCs). Despite multiple reports on human HSC aging, a unified map detailing their molecular age-related changes is lacking. We developed a consensus map of gene expression in HSCs by integrating seven single-cell datasets. This map revealed previously unappreciated heterogeneity within the HSC population. It also links...

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Identifiers and source

Literature Corpus work
94281a60-2d2a-5eb9-8ed4-c937e45790eb
DOI
10.1101/2025.09.01.673389
Open publication

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An Inflammatory and Quiescent HSC Subpopulation Expands with Age in HumansDOI 10.1101/2025.09.01.673389
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