Article

Low Transcriptional Complexity Cells Represent a Conserved, Aging-Relevant Maintenance State Overlooked by Single-Cell Transcriptomics

2026-02-17

Abstract excerpt

Whether mature tissues harbor transcriptionally quiet yet biologically functional cellular reservoirs remains largely unexplored. Here, using publicly available single-cell and single-nucleus transcriptomic datasets, we identify a previously unrecognized cellular state within fully differentiated human cell lineages characterized by low transcriptomic complexity (<1000 genes per cell) but preserved lineage identit...

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Literature Corpus work: cba31b57-e3a6-55cc-b81b-3e8ccbcb5817
DOI: 10.64898/2026.02.16.706190

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