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Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

11 Jan 2023

Abstract excerpt

Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regulation of HSPCs. In this study, we used single-cell RNA sequencing (scRNA-seq) to characterize an enriched population of human HSPCs obtained from young and elderly...

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PMID: 36629404
DOI: 10.7554/elife.79363

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