Article

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

2019-10-31

Abstract excerpt

Drug-resistant mutations often have deleterious impacts on replication fitness, posing a fitness cost that can only be overcome by compensatory mutations. However, the role of fitness cost in the evolution of drug resistance has often been overlooked in clinical studies or in vitro selection experiments, as these observations only capture the outcome of drug selection. In this study, we systematically profile the...

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Literature Corpus work: 719e1e6f-be22-5b2a-b5b9-e7e6eb798cac
DOI: 10.1101/822981

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