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Article

Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein.

PLoS genetics - 1 Mar 2016

Gupta Aditi, Adami Christoph

Abstract excerpt

Epistatic interactions between residues determine a protein's adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape. It has been shown that strong selection increases epistatic interactions as well as the ruggedness of the fitness landscape, but little is known about how the epistatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27028897
DOI: 10.1371/journal.pgen.1005960
PMCID: PMC4814079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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