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Article

Limits to detecting epistasis in the fitness landscape of HIV.

PloS one - 1 Jan 2022

Biswas Avik, Haldane Allan, Levy Ronald M

Abstract excerpt

The rapid evolution of HIV is constrained by interactions between mutations which affect viral fitness. In this work, we explore the role of epistasis in determining the mutational fitness landscape of HIV for multiple drug target proteins, including Protease, Reverse Transcriptase, and Integrase. Epistatic interactions between residues modulate the mutation patterns involved in drug resistance, with unambiguous...

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Share to Epistasis, Genetic
Share to Evolution, Molecular
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Protease

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Source

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Identifiers

PMID: 35041711
DOI: 10.1371/journal.pone.0262314
PMCID: PMC8765623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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