Article
Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance.
BMC bioinformatics - 22 Dec 2016
Su Chinh Tran-To, Ling Wei-Li, Lua Wai-Heng, Haw Yu-Xuan, Gan Samuel Ken-En
Abstract excerpt
BACKGROUND: Strategies to control HIV for improving the quality of patient lives have been aided by the Highly Active Anti-Retroviral Therapy (HAART), which consists of a cocktail of inhibitors targeting key viral enzymes. Numerous new drugs have been developed over the past few decades but viral resistances to these drugs in the targeted viral enzymes are increasingly reported. Nonetheless the acquired mutations...
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