Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strong epistatic selection on the RNA secondary structure of HIV.

PLoS pathogens - 1 Sept 2014

Assis Raquel

Abstract excerpt

A key question in evolutionary genomics is how populations navigate the adaptive landscape in the presence of epistasis, or interactions among loci. This problem can be directly addressed by studying the evolution of RNA secondary structures, for which there is constraint to maintain pairing between Watson-Crick (WC) sites. Replacement of a nucleotide at one site of a WC pair reduces fitness by disrupting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to Epistasis, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Models, Molecular

Share to Nucleic Acid Conformation

Share to RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 25210786
DOI: 10.1371/journal.ppat.1004363
PMCID: PMC4161434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strong epistatic selection on the RNA secondary structure of HIV.PMID 25210786Read ↗

Epistasis-Driven Evolution of the SARS-CoV-2 Secondary Structure.Semantic proximity Read ↗

Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein.Semantic proximity Read ↗

Evidence for positive epistasis in HIV-1.Semantic proximity Read ↗

Strain-Specific Epistasis Shapes Fitness Landscapes of APOBEC3G Antagonism By HIV-1 Vif ProteinsSemantic proximity Read ↗

Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.Semantic proximity Read ↗

Base pairing constraints drive structural epistasis in ribosomal RNA sequences.Semantic proximity Read ↗

Evolutionary Sequence and Structural Basis for the Epistatic Origins of Drug Resistance in HIVSemantic proximity Read ↗

Efficient epistasis inference via higher-order covariance matrix factorization.Semantic proximity Read ↗

Evolution. Epistasis in RNA viruses.Semantic proximity Read ↗

The importance of epistasis in the evolution of viral pathogensSemantic proximity Read ↗

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 proteaseSemantic proximity Read ↗

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.