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Article

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease.

PLoS genetics - 1 Oct 2020

Zhang Tian-Hao, Dai Lei, Barton John P, Du Yushen, Tan Yuxiang, Pang Wenwen, Chakraborty Arup K, Lloyd-Smith James O, Sun Ren

Abstract excerpt

Drug-resistant mutations often have deleterious impacts on replication fitness, posing a fitness cost that can only be overcome by compensatory mutations. However, the role of fitness cost in the evolution of drug resistance has often been overlooked in clinical studies or in vitro selection experiments, as these observations only capture the outcome of drug selection. In this study, we systematically profile the...

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Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Fitness

Share to HIV Infections

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Share to Protease Inhibitors

Share to Virus Replication

Source

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Identifiers

PMID: 33085662
DOI: 10.1371/journal.pgen.1009009
PMCID: PMC7605711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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