Article

Integrative genetic and epigenetic analysis uncovers regulatory mechanisms of autoimmune disease

2016-05-19

Abstract excerpt

Genome-wide association studies in autoimmune and inflammatory diseases (AID) have uncovered hundreds of loci mediating risk 1,2 . These associations are preferentially located in non-coding DNA regions 3,4 and in particular to tissue-specific Dnase I hypersensitivity sites (DHS) 5,6 . Whilst these analyses clearly demonstrate the overall enrichment of disease risk alleles on gene regulatory regions, they are n...

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Literature Corpus work: 2348c4de-d39b-5364-9349-76ae1ab2e928
DOI: 10.1101/054361

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