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Methylation Risk Score Identifies an Interferon-Driven SLE Subset Distinct from Polygenic Risk

2026-03-11

Abstract excerpt

<h4>Objectives</h4> The aetiopathogenesis of SLE encompasses genetic, environmental and epigenetic factors. We investigated associations between an SLE methylation risk score (MRS), HLA-DRB1*03:01, a non-HLA polygenic risk score (PRS) and clinical and immunological phenotypes. <h4>Methods</h4> DNA methylation in whole blood from patients fulfilling ≥4 ACR-82 criteria and controls were investigated using the Illu...

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Literature Corpus work
360cca5b-6227-5961-957a-7ef122d2f83e
DOI
10.64898/2026.03.10.26348007
Open publication

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Methylation Risk Score Identifies an Interferon-Driven SLE Subset Distinct from Polygenic RiskDOI 10.64898/2026.03.10.26348007
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