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Article

A Comprehensive Analysis of Type I Interferon Risk Gene Signatures in Systemic Lupus Erythematosus.

Experimental dermatology - 1 Feb 2026

Mi Xiangbin, Lai Kuan, Yan Lu, Yang Jie, Wu Hang, Wei Shanshan

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic, heterogeneous autoimmune disease influenced by various genetic and environmental factors, and recent advances have established type I interferons (IFN-I) as pivotal drivers. This study comprehensively characterises IFN-I risk gene signatures in SLE. The IFN-I-related genes were obtained from GSE185047, and then Mendelian randomisation analysis using data from the...

Topics

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Cytoskeletal Proteins
Epigenesis, Genetic
Interferon Type I
Intracellular Signaling Peptides and Proteins
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Mitochondrial Proteins

Tumor Suppressor Proteins

Source

Identifiers

PMID: 41635152
DOI: 10.1111/exd.70211

Genes

IFI44L
HERC5
IFI6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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