Article

The Lupus Epigenome Relates to Genetics, Transcription and Serological Profiles with Dependency on Molecular Subtypes and Informs Drug Discovery

2023-01-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE heterogeneity considering molecular and serological subtypes, genetics and transcriptional status, followed by drug target discovery. <h4>Metho...

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Literature Corpus work: b125b506-faf1-5fb9-aa37-b3f7fede6ed0
DOI: 10.1101/2023.01.19.22283772

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