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Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature.

Scientific reports - 2 Dec 2021

Teruel María, Barturen Guillermo, Martínez-Bueno Manuel, Castellini-Pérez Olivia, Barroso-Gil Miguel, Povedano Elena, Kerick Martin, Català-Moll Francesc, Makowska Zuzanna, Buttgereit Anne, Pers Jacques-Olivier, Marañón Concepción, Ballestar Esteban, Martin Javier, Carnero-Montoro Elena, Alarcón-Riquelme Marta E

Abstract excerpt

Primary Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics study, we confirmed a vast coordinated hypomethylation and overexpression effects in IFN-related genes, what is known as the IFN...

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Autoantibodies
DNA Methylation
Epigenomics
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Sjogren's Syndrome

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PMID: 34857786
DOI: 10.1038/s41598-021-01324-0
PMCID: PMC8640069

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