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Article

Methylation and polygenic risk scores capture different features of Systemic Lupus Erythematosus.

Rheumatology (Oxford, England) - 1 Aug 2026

Vestin Holme, Oparina Nina, Eloranta Maija-Leena, Skoglund Elisabeth, Giannakou Ioanna, Frodlund Martina, Gunnarsson Iva, Sjöwall Christopher, Svenungsson Elisabet, Rönnblom Lars, Imgenberg-Kreuz Juliana, Leonard Dag

Abstract excerpt

OBJECTIVES: The aetiopathogenesis of SLE encompasses genetic, environmental and epigenetic factors. We investigated associations between an SLE methylation risk score (MRS), HLA-DRB1*03:01, a non-HLA polygenic risk score (PRS), and clinical and immunological phenotypes. METHODS: DNA methylation in whole blood from patients fulfilling ≥4 ACR-82 criteria and from controls was investigated using the Illumina HM450K...

Topics

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Antibodies, Antinuclear
Autoantibodies
Case-Control Studies
DNA Methylation
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DRB1 Chains

Interferon-alpha

Lupus Erythematosus, Systemic

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Identifiers

PMID: 42434801
DOI: 10.1093/rheumatology/keag359
PMCID: PMC13452054

Genes

SSB
ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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