Article

Single-cell RNA-seq reveals a persistent interferon signature in immune cells from Systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment

2026-03-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Patients with Systemic lupus erythematosus (SLE) who carry a high genetic burden often experience more severe disease. To understand the molecular consequences of polygenic risk, we analyzed single-cell gene expression profiles in SLE patients stratified by genetic risk. <h4>Methods</h4> Single-cell RNA sequencing (scRNA-seq) was performed on fresh peripheral blood mononucl...

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Literature Corpus work: 579f812e-276f-5b2e-a7c3-bda675f61c44
DOI: 10.64898/2026.03.12.26348018

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