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Region- and variance-based DNA methylation analyses reveal novel disease genes and pathways for systemic lupus erythematosus

2022-11-24

Abstract excerpt

<h4>Background</h4> Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with unclear pathogenesis. DNA methylation is an important regulatory mechanism on gene expression, providing a key angle to understand disease mechanisms. To understand the pathways involved in SLE, and to develop biomarkers for its diagnosis and treatment, we analyzed DNA methylation profiles on blood cells from SLE patient...

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Literature Corpus work
a7215480-4fd3-58ca-bc4f-b0d6bb92e159
DOI
10.1101/2022.11.23.516835
Open publication

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