Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants

16 Jul 2024

Abstract excerpt

The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the epigenetic contribution to SLE heterogeneity considering molecular and serological subtypes, genetics and transcriptional status, followed by drug target discovery. We performed a stratified epigenome-wide...

Topics

Join the communities discussing this publication.

Genetic Associations and Epidemiology
Immune Cell Function and Interaction
Systemic Lupus Erythematosus Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39013887
DOI: 10.1038/s41525-024-00420-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variantsPMID 39013887Read ↗

The Lupus Epigenome Relates to Genetics, Transcription and Serological Profiles with Dependency on Molecular Subtypes and Informs Drug DiscoverySemantic proximity Read ↗

Region- and variance-based DNA methylation analyses reveal novel disease genes and pathways for systemic lupus erythematosusSemantic proximity Read ↗

DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneitySemantic proximity Read ↗

Methylation and polygenic risk scores capture different features of Systemic Lupus Erythematosus.Semantic proximity Read ↗

Methylation Risk Score Identifies an Interferon-Driven SLE Subset Distinct from Polygenic RiskSemantic proximity Read ↗

Epigenetic Variability in Systemic Lupus Erythematosus: What We Learned from Genome-Wide DNA Methylation StudiesSemantic proximity Read ↗

Advances in lupus genetics and epigenetics.Semantic proximity Read ↗

DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease ActivitySemantic proximity Read ↗

Recent advances in understanding the genetic basis of systemic lupus erythematosus.Semantic proximity Read ↗

Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus.Semantic proximity Read ↗

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.