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DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity

2025-10-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs, with childhood-onset SLE (cSLE) typically presenting a more severe course and greater genetic risk than adult-onset SLE. While DNA methylation plays a key role in lupus pathogenesis, the epigenetic landscape of cSLE remains understudied. This study aimed to investigate DNA methylati...

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Literature Corpus work
4f781d5c-1195-5259-b2d3-6edf9f5cea00
DOI
10.1101/2025.09.30.25337006
Open publication

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DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease ActivityDOI 10.1101/2025.09.30.25337006
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