Article
Centenarian Controls Increase Variant Effect-sizes by an average two-fold in an Extreme Case-Extreme Control Analysis of Alzheimer’s Disease
2018-04-13
Abstract excerpt
The detection of genetic loci associated with Alzheimer’s disease (AD) requires large numbers of cases and controls because variant effect-sizes are mostly small. We hypothesized that variant effect-sizes should increase when individuals who represent the extreme ends of a disease spectrum are considered, as their genomes are assumed to be maximally enriched or depleted with disease-associated genetic variants. We...
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Identifiers and source
- Literature Corpus work
- 35b0523c-3b1a-532b-b346-e566dd0e8f91
- DOI
- 10.1101/298018