Article
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes.
Aging - 1 May 2013
Garagnani Paolo, Giuliani Cristina, Pirazzini Chiara, Olivieri Fabiola, Bacalini Maria Giulia, Ostan Rita, Mari Daniela, Passarino Giuseppe, Monti Daniela, Bonfigli Anna Rita, Boemi Massimo, Ceriello Antonio, Genovese Stefano, Sevini Federica, Luiselli Donata, Tieri Paolo, Capri Miriam, Salvioli Stefano, Vijg Jan, Suh Yousin, Delledonne Massimo, Testa Roberto, Franceschi Claudio
Abstract excerpt
Genetic association studies of age-related, chronic human diseases often suffer from a lack of power to detect modest effects. Here we propose an alternative approach of including healthy centenarians as a more homogeneous and extreme control group. As a proof of principle we focused on type 2 diabetes (T2D) and assessed /genotypic associations of 31 SNPs associated with T2D, diabetes complications and metabolic...
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