Article

Cognitively Healthy Centenarians are genetically protected against Alzheimer’s disease specifically in immune and endo-lysosomal systems

2023-05-17

Abstract excerpt

<h4>BACKGROUND</h4> Alzheimer’s Disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages beyond 100 years without cognitive decline. We aimed to uncover the genetic factors associated with such resilience against AD. <h4>METHODS</h4> Genome-Wide-Association-Studies (GWAS) identified 86 single-nucleotide-polymorphisms (SNPs) associated with AD-risk. We studied each SNP in 2,28...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 374c1b43-a074-5303-b62f-9b6f328beeb0
DOI: 10.1101/2023.05.16.23290049

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cognitively Healthy Centenarians are genetically protected against Alzheimer’s disease specifically in immune and endo-lysosomal systemsDOI 10.1101/2023.05.16.23290049Read

Cognitively healthy centenarians are genetically protected against Alzheimer's disease.Semantic proximity Read

Increased Genetic Protection Against Alzheimer’s Disease in CentenariansSemantic proximity Read

Increased genetic protection against Alzheimer's disease in centenarians.Semantic proximity Read

Biobank-scale characterization of Alzheimer’s disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestriesSemantic proximity Read

Protective genes and pathways in Alzheimer's disease: moving towards precision interventions.Semantic proximity Read

Cognitively healthy centenarians are characterized by lower frequencies of six disease-associated<i>HLA</i>allelesSemantic proximity Read

Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s DiseaseSemantic proximity Read

Defining the Genetic Architecture of Alzheimer's Disease: Where Next.Semantic proximity Read

Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s diseaseSemantic proximity Read

Centenarians and Oldest Olds in Liguria – COOL: a multidisciplinary study to investigate the genetic determinants of cognitive well-being in Genoa, Italy. Rationale, study protocol and cohort profileSemantic proximity Read

Association of centenarian polygenic score with disability-free survival and its modification effects on aging outcomesSemantic proximity Read

Polygenic risk score analysis suggests hypothyroidism as a risk factor for Alzheimer’s diseaseSemantic proximity Read