Article
Genetic signatures of exceptional longevity in humans.
PloS one - 1 Jan 2012
Sebastiani Paola, Solovieff Nadia, Dewan Andrew T, Walsh Kyle M, Puca Annibale, Hartley Stephen W, Melista Efthymia, Andersen Stacy, Dworkis Daniel A, Wilk Jemma B, Myers Richard H, Steinberg Martin H, Montano Monty, Baldwin Clinton T, Hoh Josephine, Perls Thomas T
Abstract excerpt
Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity in 801 centenarians (median age at death 104 years) and 914 genetically matched healthy controls. Using these data, we built a genetic...
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