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Article

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.

Aging cell - 1 Oct 2020

Gutman Danielle, Lidzbarsky Gabriel, Milman Sofiya, Gao Tina, Sin-Chan Patrick, Gonzaga-Jauregui Claudia, Deelen Joris, Shuldiner Alan R, Barzilai Nir, Atzmon Gil

Abstract excerpt

Centenarians (exceptionally long-lived individuals-ELLI) are a unique segment of the population, exhibiting long human lifespan and healthspan, despite generally practicing similar lifestyle habits as their peers. We tested disease-associated mutation burden in ELLI genomes by determining the burden of pathogenic variants reported in the ClinVar and HGMD databases using data from whole exome sequencing (WES)...

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Identifiers

PMID: 32860726
DOI: 10.1111/acel.13216
PMCID: PMC7576295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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