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Article

Cognitively healthy centenarians are genetically protected against Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2024

Tesi Niccolo', van der Lee Sven, Hulsman Marc, van Schoor Natasja M, Huisman Martijn, Pijnenburg Yolande, van der Flier Wiesje M, Reinders Marcel, Holstege Henne

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied the genetic factors associated with such resilience against AD. METHODS: Genome-wide association studies identified 86 single nucleotide polymorphisms (SNPs) associated with AD risk. We estimated SNP frequency in 2281 AD cases, 3165 age-matched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38634500
DOI: 10.1002/alz.13810
PMCID: PMC11180929

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