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Burden of Common Complex Disease Variants in the Exomes of Two Healthy Centenarian Brothers.

Gerontology - 1 Jan 2015

Tindale Lauren C, Zeng Andy, Bretherick Karla L, Leach Stephen, Thiessen Nina, Brooks-Wilson Angela R

Abstract excerpt

BACKGROUND: It is not understood whether long-term good health is promoted by the absence of disease risk variants, the presence of protective variants, or both. We characterized the exomes of two exceptionally healthy centenarian brothers aged 106 and 109 years who had never been diagnosed with cancer, cardiovascular disease, diabetes, Alzheimer's disease, or major pulmonary disease. OBJECTIVE: The aim of this...

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PMID: 26066993
DOI: 10.1159/000430462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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