Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Meta‐analysis of genetic variants associated with human exceptional longevity.

Aging - 1 Sept 2013

Sebastiani Paola, Bae Harold, Sun Fangui X, Andersen Stacy L, Daw E Warwick, Malovini Alberto, Kojima Toshio, Hirose Nobuyoshi, Schupf Nicole, Puca Annibale, Perls Thomas T

Abstract excerpt

Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, but as a group in specific combinations of genetic variations, they can have a strong influence....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Coronary Artery Disease

Share to Gene Regulatory Networks

Share to Genetic Markers

Share to Genome-Wide Association Study

Share to Longevity

Source

Open in PubMed Open full text

Identifiers

PMID: 24244950
DOI: 10.18632/aging.100594
PMCID: PMC3808698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Meta‐analysis of genetic variants associated with human exceptional longevity.PMID 24244950Read ↗

Genetic signatures of exceptional longevity in humans.Semantic proximity Read ↗

The genetics of exceptional longevity: Insights from centenarians.Semantic proximity Read ↗

The genetics of exceptional human longevity.Semantic proximity Read ↗

Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity.Semantic proximity Read ↗

Genetics of exceptional longevity.Semantic proximity Read ↗

Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian StudySemantic proximity Read ↗

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.Semantic proximity Read ↗

Genetic determinants of centenarian longevity, as quantified by the 'CentPGS' score, are associated with a lower risk of multiple age-related diseases and a longer healthspan.Semantic proximity Read ↗

The genetics of exceptional human longevity.Semantic proximity Read ↗

Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum.Semantic proximity Read ↗

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.Semantic proximity Read ↗

Rare genetic coding variants associated with human longevity and protection against age-related diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.