Article
Rare genetic coding variants associated with human longevity and protection against age-related diseases.
Nature aging - 1 Sept 2021
Lin Jhih-Rong, Sin-Chan Patrick, Napolioni Valerio, Torres Guillermo G, Mitra Joydeep, Zhang Quanwei, Jabalameli M Reza, Wang Zhen, Nguyen Nha, Gao Tina, Laudes Matthias, Görg Siegfried, Franke Andre, Nebel Almut, Greicius Michael D, Atzmon Gil, Ye Kenny, Gorbunova Vera, Ladiges Warren C, Shuldiner Alan R, Niedernhofer Laura J, Robbins Paul D, Milman Sofiya, Suh Yousin, Vijg Jan, Barzilai Nir, Zhang Zhengdong D
Abstract excerpt
Extreme longevity in humans has a strong genetic component, but whether this involves genetic variation in the same longevity pathways as found in model organisms is unclear. Using whole-exome sequences of a large cohort of Ashkenazi Jewish centenarians to examine enrichment for rare coding variants, we found most longevity-associated rare coding variants converge upon conserved insulin/insulin-like growth...
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