A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.

doi:10.3390/ijms24010116

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Article

A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.

International journal of molecular sciences - 21 Dec 2022

Bae Harold, Gurinovich Anastasia, Karagiannis Tanya T, Song Zeyuan, Leshchyk Anastasia, Li Mengze, Andersen Stacy L, Arbeev Konstantin, Yashin Anatoliy, Zmuda Joseph, An Ping, Feitosa Mary, Giuliani Cristina, Franceschi Claudio, Garagnani Paolo, Mengel-From Jonas, Atzmon Gil, Barzilai Nir, Puca Annibale, Schork Nicholas J, Perls Thomas T, Sebastiani Paola

Abstract excerpt

We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls. The analysis identified a locus in CDKN2B-AS1 (rs6475609, p = 7.13 × 10-8) that almost reached genome-wide significance and four additional loci that were...

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PMID: 36613555
DOI: 10.3390/ijms24010116
PMCID: PMC9820206

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CDKN2B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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