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Article

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.

PLoS genetics - 1 Dec 2015

Fortney Kristen, Dobriban Edgar, Garagnani Paolo, Pirazzini Chiara, Monti Daniela, Mari Daniela, Atzmon Gil, Barzilai Nir, Franceschi Claudio, Owen Art B, Kim Stuart K

Abstract excerpt

We developed a new statistical framework to find genetic variants associated with extreme longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large studies of age-related disease in order to narrow the search for SNPs associated with longevity. To gain support for our approach, we first show there is an overlap between loci involved in disease and loci associated with extreme...

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Identifiers

PMID: 26677855
DOI: 10.1371/journal.pgen.1005728
PMCID: PMC4683064

Genes

APOE
TOMM40
ABO
ATXN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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