Article

High-resolution DNA accessibility profiles increase the discovery and interpretability of genetic associations

2016-08-23

Abstract excerpt

Genetic risk for common autoimmune diseases is influenced by hundreds of small effect, mostly non-coding variants, enriched in regulatory regions active in adaptive-immune cell types. DNaseI hypersensitivity sites (DHSs) are a genomic mark for regulatory DNA. Here, we generated a single DHSs annotation from fifteen deeply sequenced DNase-seq experiments in adaptive-immune as well as non-immune cell types. Using th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 359f5d62-7d6b-5b6d-8199-9819ad798811
DOI: 10.1101/070268

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-resolution DNA accessibility profiles increase the discovery and interpretability of genetic associationsDOI 10.1101/070268Read

Integrative Genetic and Epigenetic Analysis Uncovers Regulatory Mechanisms of Autoimmune Disease.Semantic proximity Read

Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease riskSemantic proximity Read

Integrative Data Analysis to Uncover Transcription Factors Involved in Gene Dysregulation of Nine Autoimmune and Inflammatory DiseasesSemantic proximity Read

Index and biological spectrum of accessible DNA elements in the human genomeSemantic proximity Read

Integrative genetic and epigenetic analysis uncovers regulatory mechanisms of autoimmune diseaseSemantic proximity Read

Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci.Semantic proximity Read

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibilitySemantic proximity Read

Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 CellsSemantic proximity Read

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.Semantic proximity Read

Genetic and epigenetic fine mapping of causal autoimmune disease variants.Semantic proximity Read

Population-scale multiome immune cell atlas reveals complex disease driversSemantic proximity Read