Article

Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells

2018-04-01

Abstract excerpt

Transcriptional regulatory networks (TRNs) provide insight into cellular behavior by describing interactions between transcription factors (TFs) and their gene targets. The Assay for Transposase Accessible Chromatin (ATAC)-seq, coupled with transcription-factor motif analysis, provides indirect evidence of chromatin binding for hundreds of TFs genome-wide. Here, we propose methods for TRN inference in a mammalian...

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Literature Corpus work: 0e731d4c-b4b2-5273-ab0a-a0bb7d50ddfb
DOI: 10.1101/292987

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