Article

Colibactin-associated mutations in the human colon appear to reflect anatomy and early exposure, not oncogenesis

2026-04-15

Abstract excerpt

Colorectal cancer (CRC) is the second leading cause of cancer death globally and the number one cause of cancer death in people under 50 years old. The reasons for the rise of early-onset CRC are unknown, and while anatomically distinct subtypes of CRC have substantial clinical and molecular associations, the etiology of region-specific disease, such as early-onset CRC’s enrichment in the distal colon, remains unc...

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Literature Corpus work: 355eb97e-2bdd-50ec-a130-c1550b2cadea
DOI: 10.64898/2026.04.13.26350783

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