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Early-Onset Colorectal Cancer: From Epidemiologic Shift to Life-Course Carcinogenesis and Age-Attuned Care.

Current oncology reports - 20 Aug 2026

Grześkiewicz-Szostak Magda, Gęca Katarzyna, Skórzewska Magdalena

Abstract excerpt

PURPOSE OF REVIEW: Early-onset colorectal cancer (EOCRC), conventionally defined as colorectal cancer diagnosed before the age of 50 years, has become one of the most important and unsettling epidemiologic shifts in gastrointestinal oncology. This review critically synthesizes recent evidence on EOCRC epidemiology, risk architecture, life-course carcinogenesis, molecular and microbiome-associated mechanisms,...

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Identifiers

PMID: 42618835
DOI: 10.1007/s11912-026-01815-1
PMCID: PMC13490218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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