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Article

Contribution of pks+ E. coli mutations to colorectal carcinogenesis.

Nature communications - 29 Nov 2023

Chen Bingjie, Ramazzotti Daniele, Heide Timon, Spiteri Inmaculada, Fernandez-Mateos Javier, James Chela, Magnani Luca, Graham Trevor A, Sottoriva Andrea

Abstract excerpt

The dominant mutational signature in colorectal cancer genomes is C > T deamination (COSMIC Signature 1) and, in a small subgroup, mismatch repair signature (COSMIC signatures 6 and 44). Mutations in common colorectal cancer driver genes are often not consistent with those signatures. Here we perform whole-genome sequencing of normal colon crypts from cancer patients, matched to a previous multi-omic tumour...

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Source

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Identifiers

PMID: 38030613
DOI: 10.1038/s41467-023-43329-5
PMCID: PMC10687070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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