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Article

Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer.

Cancer cell - 8 Nov 2021

Berger Hilmar, Meyer Thomas F

Abstract excerpt

Gut colonization by colibactin-producing bacteria is associated with colorectal cancer. A mutational signature of this genotoxin in human cancer indicates causality but only partially accounts for cell transformation. Instead, the failure of adequately resolving DNA damage causes genomic aberrations and chromosomal instability, constituting the main starting point for colibactin-driven cancer.

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Identifiers

PMID: 34752751
DOI: 10.1016/j.ccell.2021.10.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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