Article
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
Nature - 1 Apr 2020
Pleguezuelos-Manzano Cayetano, Puschhof Jens, Rosendahl Huber Axel, van Hoeck Arne, Wood Henry M, Nomburg Jason, Gurjao Carino, Manders Freek, Dalmasso Guillaume, Stege Paul B, Paganelli Fernanda L, Geurts Maarten H, Beumer Joep, Mizutani Tomohiro, Miao Yi, van der Linden Reinier, van der Elst Stefan, Garcia K Christopher, Top Janetta, Willems Rob J L, Giannakis Marios, Bonnet Richard, Quirke Phil, Meyerson Matthew, Cuppen Edwin, van Boxtel Ruben, Clevers Hans
Abstract excerpt
Various species of the intestinal microbiota have been associated with the development of colorectal cancer1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes that synthesize colibactin3. This compound is believed to alkylate DNA on adenine residues4,5 and induces...
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