Article
Geographic and age variations in mutational processes in colorectal cancer.
Nature - 1 Jul 2025
Díaz-Gay Marcos, Dos Santos Wellington, Moody Sarah, Kazachkova Mariya, Abbasi Ammal, Steele Christopher D, Vangara Raviteja, Senkin Sergey, Wang Jingwei, Fitzgerald Stephen, Bergstrom Erik N, Khandekar Azhar, Otlu Burçak, Abedi-Ardekani Behnoush, de Carvalho Ana Carolina, Cattiaux Thomas, Penha Ricardo Cortez Cardoso, Gaborieau Valérie, Chopard Priscilia, Carreira Christine, Cheema Saamin, Latimer Calli, Teague Jon W, Mukeriya Anush, Zaridze David, Cox Riley, Albert Monique, Phouthavongsy Larry, Gallinger Steven, Malekzadeh Reza, Niavarani Ahmadreza, Miladinov Marko, Erić Katarina, Milosavljevic Sasa, Sangrajrang Suleeporn, Curado Maria Paula, Aguiar Samuel, Reis Rui Manuel, Reis Monise Tadin, Romagnolo Luis Gustavo, Guimarães Denise Peixoto, Holcatova Ivana, Kalvach Jaroslav, Vaccaro Carlos Alberto, Piñero Tamara Alejandra, Świątkowska Beata, Lissowska Jolanta, Roszkowska-Purska Katarzyna, Huertas-Salgado Antonio, Shibata Tatsuhiro, Shiba Satoshi, Sangkhathat Surasak, Chitapanarux Taned, Roshandel Gholamreza, Ashton-Prolla Patricia, Damin Daniel C, de Oliveira Francine Hehn, Humphreys Laura, Lawley Trevor D, Perdomo Sandra, Stratton Michael R, Brennan Paul, Alexandrov Ludmil B
Abstract excerpt
Incidence rates of colorectal cancer vary geographically and have changed over time1. Notably, in the past two decades, the incidence of early-onset colorectal cancer, which affects individuals below 50 years of age, has doubled in many countries2-5. The reasons for this increase are unknown. Here we investigate whether mutational processes contribute to geographic and age-related differences by examining 981...
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