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Article

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients.

BMC cancer - 18 Jan 2024

Terlouw Diantha, Boot Arnoud, Ducarmon Quinten R, Nooij Sam, Suerink Manon, van Leerdam Monique E, van Egmond Demi, Tops Carli M, Zwittink Romy D, Ruano Dina, Langers Alexandra M J, Nielsen Maartje, van Wezel Tom, Morreau Hans

Abstract excerpt

BACKGROUND: Colibactin, a genotoxin produced by polyketide synthase harboring (pks+) bacteria, induces double-strand breaks and chromosome aberrations. Consequently, enrichment of pks+Escherichia coli in colorectal cancer and polyposis suggests a possible carcinogenic effect in the large intestine. Additionally, specific colibactin-associated mutational signatures; SBS88 and ID18 in the Catalogue of Somatic...

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Identifiers

PMID: 38238650
DOI: 10.1186/s12885-024-11849-y
PMCID: PMC10797792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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