Article

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients

2023-06-06

Abstract excerpt

Colibactin, a genotoxin produced by polyketide synthase harboring ( pks + ) bacteria, induces double-strand breaks and chromosome aberrations. Consequently, enrichment of pks + Escherichia coli in colorectal cancer and polyposis suggests a possible carcinogenic effect in the large intestine. Additionally, specific colibactin-associated mutational signatures; SBS88 and ID18 in the Catalogue of Somatic Mutations in...

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Literature Corpus work: 8838fb1f-a0fd-59fb-920e-508af16f5b6f
DOI: 10.1101/2023.06.02.23290324

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